nash,k

nash,k     pubmed papers reports books mesh-terms authors users fp7 partner add bioinfo.pl bioinformatics lab to your fp7 application bioinfo.pl username: password: register forgot password login register to comment articles, reports and participate in mesh term forums register to monitor favorite articles, reports, mesh-terms, authors, users register to publish reports in the bioinfobank library and become editor register to create your own user record to promote your scientific activity    recommending commenting favorite    papers recom. cited nash k (k) 0 0 0 35 0 15 nash k (kate) 0 0 0 3 0 0 nash k (kathleen) 0 0 0 2 0 0 nash k (kelly) 0 0 0 1 0 0 nash k (kenneth) 0 0 0 1 0 0 nash k (kevin) 0 0 0 9 0 2 nash k (kyle) 0 0 0 1 0 0     latest paper: am j obstet gynecol. 2007 sep ;197 (3):253.e1-3 17826408 are women who have had a preterm twin delivery at greater risk of preterm birth in a subsequent singleton pregnancy? [my paper] francesca l facco , kate nash , william a grobman objective: the purpose of this study was to determine whether preterm birth of twins is associated with an increased risk of preterm birth in a subsequent singleton pregnancy. study design: all patients who delivered a twin gestation and a subsequent singleton pregnancy at northwestern memorial hospital during a 10-year period were identified. we used a cohort study design, comparing the outcomes of the singleton pregnancies in women with preterm twin deliveries to those pregnancies with term twin deliveries. results: one hundred sixty-seven women delivered twins followed by a singleton pregnancy. women whose twin delivery was preterm (n = 99) were more likely than those who had delivered a term twin pregnancy (n = 68) to deliver a subsequent preterm singleton pregnancy (13.1% vs 2.9%; odds ratio, 5.0; 95% ci, 1.1, 22.9). conclusion: preterm birth of twins is associated with an increased risk of preterm delivery in a subsequent singleton pregnancy. br j sociol. 2007 sep ;58 (3):417-35 17727501 the pinochet case: cosmopolitanism and intermestic human rights. [my paper] kate nash this article explores the pinochet case, widely heralded as a landmark, as a case of 'intermestic' human rights that raises difficult normative and empirical questions concerning cosmopolitan justice. the article is a contribution to the sociology of human rights from the perspective of methodological cosmopolitanism, developing conceptual tools and methods to study how cosmopolitanizing state institutions and cultural norms are inter-related. the argument is made that in order to understand issues of cosmopolitan justice, sociologists must give more consideration to political culture. j fam plann reprod health care. 2007 apr ;33 (2):78 17407671 development of upcash (update in contraception and sexual health) flexible continuing medical education. [my paper] fran reader , caroline marfleet , kate nash j virol. 2007 mar 14; : 17360744 purification of host cell enzymes involved in adeno-associated virus dna replication. [my paper] kevin nash , weijun chen , william f mcdonald , xiaohuai zhou , nicholas muzyczka aav replicates its dna by a modified rolling circle mechanism that exclusively uses leading strand displacement synthesis. to identify the enzymes directly involved in aav dna replication, we fractionated adenovirus infected crude extracts and tested them in an in vitro replication system that required the presence of the aav encoded rep protein and the aav origins of dna replication, thus faithfully reproducing in vivo viral dna replication. fractions that contained replication factor c (rfc), and proliferating cell nuclear antigen (pcna) were found to be essential for reconstituting aav dna replication. these could be substituted by purified pcna and rfc to retain full activity. we also found that fractions containing polymerase delta, but not polymerase epsilon or alpha, were capable of replicating aav dna in vitro. this was confirmed when highly purified polymerase delta complex purified from baculovirus expression clones was used. curiously, as the components of the dna replication system were purified, neither the cellular ssdna binding protein (rpa) nor the adenovirus encoded dna binding protein (dbp) was found to be essential for dna replication; both only modestly stimulated dna synthesis on an aav template. also, in addition to polymerase delta, rfc and pcna, an as yet unidentified factor(s) is required for aav dna replication, which appeared to be enriched in ad infected cells. finally, the absence of any apparent cellular dna helicase requirement led us to develop an artificial aav replication system in which pol delta, rfc, and pcna were substituted with t4 dna polymerase and gp32 protein. this system was capable of supporting aav dna replication demonstrating that under some conditions the rep helicase activity can function to unwind duplex dna during strand displacement synthesis. j emerg nurs. 2007 feb ;33 (1):14-20 17258047 evaluation of the fast track unit of a university emergency department. [my paper] kathleen nash , brian zachariah , jennifer nitschmann , benjamin psencik introduction: the purpose of this study was to evaluate the efficacy of the newly developed fast track (ft) area in a university-affiliated emergency department. the goals of the ft unit included reducing patients' length of stay, improving patients' satisfaction, and decreasing ed overcrowding. methods: an exploratory descriptive design used to investigate length of stay in the emergency department, the rate of patients who left without being seen, unscheduled return visits to the emergency department within 72 hours of being seen, and patient satisfaction. results: during the evaluation period, 5995 patients were seen in the ed fast track area. the average time patients spent in the emergency department was 4.36 hours. the average time in room for the ft area was 1.97 hours. the left-without-being-seen rate for this time period for the main emergency department was 7%; the rate for the ft area was 4%. additionally, 100% of respondents who completed a patient satisfaction survey in the ft area rated the care received by the nurse practitioner (np) as good or excellent. conclusions: although the average time in room and overall length of stay did not meet expectations, patients did move more quickly through the department after the addition of the ft unit. patient satisfaction data suggested that the ft staffed by nps is a welcome addition to the emergency department. the findings provide direction for the future study of np utilization in the emergency department. neurosci biobehav rev. 2006 aug 24; : 16934870 novel approaches to the diagnosis of fetal alcohol spectrum disorder. [my paper] daniela l caprara , kelly nash , rachel greenbaum , joanne rovet , gideon koren the diagnosis of fetal alcohol spectrum disorder is a difficult task, especially in cases where clear, physical markers of in utero alcohol exposure are not apparent. reviewed in the following paper are some older tools for screening alcohol use in pregnancy and present novel approaches to the diagnosis of fasd, including ethanol biomarker development to behavioural phenotyping. improving current fasd diagnostic methodology through more novel approaches may provide the possibility of earlier and wider diagnosis, allowing intervention and treatment at stages where the advanced effects of alcohol can still be mitigated. arch womens ment health. 2006 may 3; : 16673042 identifying the behavioural phenotype in fetal alcohol spectrum disorder: sensitivity, specificity and screening potential. [my paper] k nash , j rovet , r greenbaum , e fantus , i nulman , g koren background: in most cases of fetal alcohol spectrum disorder (fasd), the pathognomonic facial features are absent making diagnosis challenging, if not impossible, particularly when no history of maternal drinking is available. also because fasd is often comorbid with attention deficit hyperactivity disorder (adhd), children with fasd are frequently improperly diagnosed and receive the wrong treatment. since access to psychological testing is typically limited or non-existent in remote areas, other diagnostic methods are needed to provide necessary interventions.objectives: to determine if a characteristic behavioural phenotype distinguishes children with fasd from typically developing children and children with adhd and use this information to create a screening tool for fasd diagnosis.methods: parents and caregivers completed the child behavior checklist (cbcl), a well-established standardized tool for evaluating children's behavioural problems. results from 30 children with fetal alcohol syndrome or alcohol-related neurodevelopmental disability, 30 children with adhd, and 30 typically developing healthy children matched for age and socioeconomic status with fasd were analyzed. based on our previous work, 12 cbcl items that significantly differentiated fasd and control groups were selected for further analyses. stepwise discriminant function analysis identified behavioural characteristics most strongly differentiating groups and receiver operating characteristics (roc) curve analyses determined sensitivity and specificity of different item combinations.results: seven items reflecting hyperactivity, inattention, lying and cheating, lack of guilt, and disobedience significantly differentiated children with fasd from controls. roc analyses showed scores of 6 or higher on these items differentiated groups with a sensitivity of 86%, specificity of 82%. for fasd and adhd, two combinations of items significantly differentiated groups with high sensitivity and specificity (i) no guilt, cruelty, and acts young (sensitivity = 70%; specificity = 80% (ii) acts young, cruelty, no guilt, lying or cheating, steals from home, and steals outside (sensitivity = 81%; specificity = 72%). these items were used to construct a potential fasd screening tool.conclusions: our findings identifying the behavioural characteristics differentiating children with fasd from typically developing children or children with adhd have the potential for development of an empirically derived tool for fasd tool to be used in remote areas where psychological services are not readily available. this technique may speed up diagnosis and intervention for children without ready access to formal assessments. acad psychiatry. 2006 ;30 (1):55-62 16473996 a developmental model for enhancing research training during psychiatry residency. [my paper] andrew r gilbert , james d tew jr , charles f reynolds iii , harold a pincus , neal ryan , kenneth nash , david j kupfer objective: the authors describe a developmental model for enhancing residency research training for careers in academic psychiatry. over the past 10 years, the university of pittsburgh department of psychiatry has developed a research track (rt) for its residents. while the department's plan has been to address the critical need of training physician-scientists in psychiatry, the rt continues to evolve as a structured extension of the university's residency-training program. recently, the university's departmental leadership has taken several steps that address regulatory, institutional, and personal barriers to residency research training put forth by the 2003 institute of medicine (iom) report. methods: the authors outline a model of residency research training, elements of which should be exportable to the majority of u.s. psychiatry residency programs. results: for residents in the rt, up to 50% of time in pgy-3 and up to 75% of time in pgy-4 can be devoted to research-related activities. the authors currently have 13 residents and fellows in their track. over the past 10 years, 15 of 33 rt residents have become research postdocs or full-time grant-funded researchers in academic positions. conclusion: the authors' experience suggests that it is possible to organize and implement an rt during psychiatry residency within the parameters presented by the psychiatry residency review committee (rrc). mol ther. 2006 jan 10; : 16412695 recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. [my paper] ronald j mandel , fredric p manfredsson , kevin d foust , aaron rising , sharon reimsnider , kevin nash , corinna burger recombinant adeno-associated virus (raav) is derived from a small human parvovirus with an excellent safety profile. in addition, this viral vector efficiently transduces and supports long-term transgene expression in the nervous system. these properties make raav a reasonable candidate vector for treating neurological disorders. indeed, raav is currently being used in five early stage clinical trials for various neurodegenerative disorders. therefore, we will review the currently available preclinical data using raav in animal models of central nervous system (cns) disorders. moreover, potential caveats for raav-based gene therapy in the cns are also presented. mol ther. 2005 dec ;12:1217-25 16213797 successful production of pseudotyped raav vectors using a modified baculovirus expression system. [my paper] erik kohlbrenner , george aslanidi , kevin nash , stanislav shklyaev , martha campbell-thompson , barry j byrne , richard o snyder , nicholas muzyczka , kenneth h warrington jr , sergei zolotukhin scalable production of raav vectors remains a major obstacle to the clinical application of this prototypical gene therapy vector. a recently developed baculovirus-based production protocol (m. urabe et al., 2002, hum. gene ther. 13, 1935-1943) found limited applications due to the system's design. here we report a detailed analysis of the stability of the original baculovirus system components bacrep, bacvp, and transgene cassette-containing bacgfp. all of the baculovirus helpers analyzed were prone to passage-dependent loss-of-function deletions resulting in considerable decreases in raav titers. to alleviate the instability and to extend the baculovirus platform to other raav serotypes, we have modified both rep- and cap-encoding components of the original system. the modifications include a parvoviral phospholipase a2 domain swap allowing production of infectious raav8 vectors in vivo. alternatively, an infectious raav8 (or raav5) vector incorporating the aav2 vp1 capsid protein in a mosaic vector particle with aav8 capsid proteins was produced using a novel baculovirus vector. in this vector, the level of aav2 vp1 expression is controlled with a "riboswitch," a self-cleaving ribozyme controlled by toyocamycin in the "on" mode. the redesigned baculovirus system improves our capacity for raav manufacturing by making this production platform more applicable to other existing serotypes.   by bioinfobank institute

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